The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRα kinase exhibits a significantly different signaling pattern comp...

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Detalles Bibliográficos
Publicado en:JAKSTAT
Autores principales: Haan, Serge, Bahlawane, Christelle, Wang, Jiali, Nazarov, Petr V, Muller, Arnaud, Eulenfeld, René, Haan, Claude, Rolvering, Catherine, Vallar, Laurent, Satagopam, Venkata P, Sauter, Thomas, Wiesinger, Monique Yvonne
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583054/
https://ncbi.nlm.nih.gov/pubmed/26413425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21623996.2015.1062596
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