Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b′x Domain

Quercetin-3-rutinoside inhibits thrombus formation in a mouse model by inhibiting extracellular protein disulfide isomerase (PDI), an enzyme required for platelet thrombus formation and fibrin generation. Prior studies have identified PDI as a potential target for novel antithrombotic agents. Using...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Lin, Lin, Gopal, Srila, Sharda, Anish, Passam, Freda, Bowley, Sheryl R., Stopa, Jack, Xue, Guangpu, Yuan, Cai, Furie, Barbara C., Flaumenhaft, Robert, Huang, Mingdong, Furie, Bruce
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583019/
https://ncbi.nlm.nih.gov/pubmed/26240139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666180
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