Fibrin activates GPVI in human and mouse platelets

The glycoprotein VI (GPVI)-Fc receptor γ (FcRγ) chain is the major platelet signaling receptor for collagen. Paradoxically, in a FeCl(3) injury model, occlusion, but not initiation of thrombus formation, is delayed in GPVI-deficient and GPVI-depleted mice. In this study, we demonstrate that GPVI is...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Alshehri, Osama M., Hughes, Craig E., Montague, Samantha, Watson, Stephanie K., Frampton, Jon, Bender, Markus, Watson, Steve P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582337/
https://ncbi.nlm.nih.gov/pubmed/26282541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-641654
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