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Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti–human platelet agents
GPVI is a 62-kDa membrane glycoprotein expressed in noncovalent association with the Fc receptor γ chain on human and murine platelets and serves as the major activating receptor for collagen. GPVI-specific antibodies have the capacity to specifically deplete GPVI from mouse and human platelets in v...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society of Hematology
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895852/ https://ncbi.nlm.nih.gov/pubmed/16569773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-07-2937 |
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