Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma

PURPOSE: Aurora A kinase (AAK) is expressed exclusively during mitosis, and plays a critical role in centrosome duplication and spindle formation. Alisertib is a highly selective AAK inhibitor that has demonstrated marked clinical activity of alisertib across a spectrum of lymphomas, though particul...

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Publicat a:Clin Cancer Res
Autors principals: Zullo, Kelly M., Guo, Yige, Cooke, Laurence, Jirau-Serrano, Xavier, Mangone, Michael, Scotto, Luigi, Amengual, Jennifer E., Mao, Yinghui, Nandakumar, Renu, Cremers, Serge, Duong, Jimmy, Mahadevan, Daruka, O’Connor, Owen A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581881/
https://ncbi.nlm.nih.gov/pubmed/25878331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0033
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