Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug : Drug Combination with Ibrutinib

PURPOSE: Pan-class I/II histone deacetylase (HDAC) inhibitors are effective treatments for select lymphomas. Isoform-selective HDAC inhibitors are emerging as potentially more targeted agents. ACY-1215 (ricolinostat) is a first in class selective HDAC6 inhibitor. To better understand the discrete fu...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Amengual, Jennifer E., Prabhu, Sathyen A., Lombardo, Maximilian, Zullo, Kelly, Johannet, Paul M., Gonzalez, Yulissa, Scotto, Luigi, Serrano, Xavier Jirau, Wei, Ying, Duong, Jimmy, Nandakumar, Renu, Cremers, Serge, Verma, Akanksha, Elemento, Olivier, O'Connor, Owen A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474138/
https://ncbi.nlm.nih.gov/pubmed/27993968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2022
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