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Atomic description of the immune complex involved in heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is an autoimmune thrombotic disorder caused by immune complexes containing platelet factor 4 (PF4), antibodies to PF4 and heparin or cellular glycosaminoglycans (GAGs). Here we solve the crystal structures of the: (1) PF4 tetramer/fondaparinux complex, (2) PF4...
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Udgivet i: | Nat Commun |
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Main Authors: | , , , , , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Nature Pub. Group
2015
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4580983/ https://ncbi.nlm.nih.gov/pubmed/26391892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9277 |
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