Atomic description of the immune complex involved in heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is an autoimmune thrombotic disorder caused by immune complexes containing platelet factor 4 (PF4), antibodies to PF4 and heparin or cellular glycosaminoglycans (GAGs). Here we solve the crystal structures of the: (1) PF4 tetramer/fondaparinux complex, (2) PF4...

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Publicat a:Nat Commun
Autors principals: Cai, Zheng, Yarovoi, Serge V., Zhu, Zhiqiang, Rauova, Lubica, Hayes, Vincent, Lebedeva, Tatiana, Liu, Qun, Poncz, Mortimer, Arepally, Gowthami, Cines, Douglas B., Greene, Mark I.
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580983/
https://ncbi.nlm.nih.gov/pubmed/26391892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9277
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