Isoform-selective phosphoinositide 3′-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell–mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach

Phosphoinositide 3-kinases (PI3Ks) are among the most frequently activated signaling pathways in cancer. In chronic lymphocytic leukemia (CLL), signals from the microenvironment are critical for expansion of the malignant B cells, and cause constitutive activation of PI3Ks. CXCR4 is a key receptor f...

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Publicado en:Blood
Autores principales: Niedermeier, Matthias, Hennessy, Bryan T., Knight, Zachary A., Henneberg, Marina, Hu, Jianhua, Kurtova, Antonina V., Wierda, William G., Keating, Michael J., Shokat, Kevan M., Burger, Jan A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580965/
https://ncbi.nlm.nih.gov/pubmed/19318683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-165068
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