Mutation deep within an intron of MSH2 causes Lynch syndrome

Lynch syndrome, a heritable form of cancer predisposition, is caused by germline mutations within genes of the DNA mismatch repair family, and can be rapidly identified in young onset cancer patients through the detection of loss of expression of at least one of these genes in tumour samples. To dat...

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Bibliografiska uppgifter
I publikationen:Fam Cancer
Huvudupphovsmän: Clendenning, Mark, Buchanan, Daniel D., Walsh, Michael D., Nagler, Belinda, Rosty, Christophe, Thompson, Bryony, Spurdle, Amanda B., Hopper, John L., Jenkins, Mark A., Young, Joanne P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580736/
https://ncbi.nlm.nih.gov/pubmed/21360204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-011-9427-0
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