Mutation deep within an intron of MSH2 causes Lynch syndrome

Lynch syndrome, a heritable form of cancer predisposition, is caused by germline mutations within genes of the DNA mismatch repair family, and can be rapidly identified in young onset cancer patients through the detection of loss of expression of at least one of these genes in tumour samples. To dat...

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Detalhes bibliográficos
Publicado no:Fam Cancer
Main Authors: Clendenning, Mark, Buchanan, Daniel D., Walsh, Michael D., Nagler, Belinda, Rosty, Christophe, Thompson, Bryony, Spurdle, Amanda B., Hopper, John L., Jenkins, Mark A., Young, Joanne P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580736/
https://ncbi.nlm.nih.gov/pubmed/21360204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-011-9427-0
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