Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors

Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states includi...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Congdon, Molly D., Childress, Elizabeth S., Patwardhan, Neeraj N., Gumkowski, James, Morris, Emily A., Kharel, Yugesh, Lynch, Kevin R., Santos, Webster L.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580500/
https://ncbi.nlm.nih.gov/pubmed/25862200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.041
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