Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain

INTRODUCTION: The application of high-throughput genomic approaches has revealed 24 novel risk loci for Alzheimer’s disease (AD). We recently reported that the bridging integrator 1 (BIN1) risk gene is linked to Tau pathology. RESULTS: We used glutathione S-transferase pull-down assays and nuclear m...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Sottejeau, Yoann, Bretteville, Alexis, Cantrelle, François-Xavier, Malmanche, Nicolas, Demiaute, Florie, Mendes, Tiago, Delay, Charlotte, Alves Dos Alves, Harmony, Flaig, Amandine, Davies, Peter, Dourlen, Pierre, Dermaut, Bart, Laporte, Jocelyn, Amouyel, Philippe, Lippens, Guy, Chapuis, Julien, Landrieu, Isabelle, Lambert, Jean-Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580349/
https://ncbi.nlm.nih.gov/pubmed/26395440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0237-8
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