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Significantly shorter Fe-S bond in cytochrome P450-I is consistent with greater reactivity relative to chloroperoxidase

Cytochrome P450 (P450) and chloroperoxidase (CPO) are thiolate ligated heme proteins that catalyze the activation of carbon hydrogen bonds. The principal intermediate in these reactions is a ferryl radical species called compound I. P450 compound I (P450-I) is significantly more reactive than CPO-I,...

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Pubblicato in:Nat Chem
Autori principali: Krest, Courtney M., Silakov, Alexey, Rittle, Jonathan, Yosca, Timothy H., Onderko, Elizabeth L., Calixto, Julio C., Green, Michael T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580274/
https://ncbi.nlm.nih.gov/pubmed/26291940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2306
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