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Significantly shorter Fe-S bond in cytochrome P450-I is consistent with greater reactivity relative to chloroperoxidase

Cytochrome P450 (P450) and chloroperoxidase (CPO) are thiolate ligated heme proteins that catalyze the activation of carbon hydrogen bonds. The principal intermediate in these reactions is a ferryl radical species called compound I. P450 compound I (P450-I) is significantly more reactive than CPO-I,...

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Udgivet i:Nat Chem
Main Authors: Krest, Courtney M., Silakov, Alexey, Rittle, Jonathan, Yosca, Timothy H., Onderko, Elizabeth L., Calixto, Julio C., Green, Michael T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580274/
https://ncbi.nlm.nih.gov/pubmed/26291940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2306
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