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A New Look at the Role of Thiolate Ligation in Cytochrome P450

Protonated ferryl (or iron(IV)hydroxide) intermediates have been characterized in several thiolate-ligated heme proteins that are known to catalyze C-H bond activation. The basicity of the ferryl intermediates in these species has been proposed to play a critical role in facilitating this chemistry,...

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Bibliographic Details
Published in:J Biol Inorg Chem
Main Authors: Yosca, Timothy H., Ledray, Aaron P., Ngo, Joanna, Green, Michael T.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640440/
https://ncbi.nlm.nih.gov/pubmed/28091754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-016-1430-3
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