Attenuated Human Parainfluenza Virus Type 1 (HPIV1) Expressing the Fusion Glycoprotein of Human Respiratory Syncytial Virus (RSV) as a Bivalent HPIV1/RSV Vaccine

Live attenuated recombinant human parainfluenza virus type 1 (rHPIV1) was investigated as a vector to express the respiratory syncytial virus (RSV) fusion (F) glycoprotein, to provide a bivalent vaccine against RSV and HPIV1. The RSV F gene was engineered to include HPIV1 transcription signals and i...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Mackow, Natalie, Amaro-Carambot, Emérito, Liang, Bo, Surman, Sonja, Lingemann, Matthias, Yang, Lijuan, Collins, Peter L., Munir, Shirin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580189/
https://ncbi.nlm.nih.gov/pubmed/26223633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01380-15
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