Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biological activity of IL-33 at its receptor ST2 is ra...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579851/
https://ncbi.nlm.nih.gov/pubmed/26365875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9327
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