Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage

Interleukin (IL)-33 is an IL-1 family alarmin released from damaged epithelial and endothelial barriers to elicit immune responses and allergic inflammation via its receptor ST2. Serine proteases released from neutrophils, mast cells and cytotoxic lymphocytes have been proposed to process the N-term...

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Publicado no:Sci Rep
Main Authors: Scott, Ian C., Majithiya, Jayesh B., Sanden, Caroline, Thornton, Peter, Sanders, Philip N., Moore, Tom, Guscott, Molly, Corkill, Dominic J., Erjefält, Jonas S., Cohen, E. Suzanne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820248/
https://ncbi.nlm.nih.gov/pubmed/29463838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21589-2
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