Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length

Almost 400 genes affect yeast telomere length, including Est1, which is critical for recruitment and activation of telomerase. Here we use mass spectrometry to identify novel telomerase regulators by their co-purification with the telomerase holoenzyme. In addition to all known subunits, over 100 pr...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Lin, Kah-Wai, McDonald, Karin R., Guise, Amanda J., Chan, Angela, Cristea, Ileana M., Zakian, Virginia A.
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579843/
https://ncbi.nlm.nih.gov/pubmed/26365526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9290
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