Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication

Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase is the key regulated step during DNA replication termination in eukaryotes, involving ubiquitylation of the Mcm7 helicase subunit, leading to a disassembly process that requires the Cdc48 “segregase”. Here, we employ a screen to identify partners...

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Pubblicato in:Cell Rep
Autori principali: Maric, Marija, Mukherjee, Progya, Tatham, Michael H., Hay, Ronald, Labib, Karim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2017
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382235/
https://ncbi.nlm.nih.gov/pubmed/28355556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.020
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