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Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

Chromosome replication is initiated by a universal mechanism in eukaryotic cells, involving the assembly and activation at replication origins of the CMG (Cdc45-MCM-GINS) DNA helicase, which is essential for the progression of replication forks. Disassembly of CMG is likely to be a key regulated ste...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Maric, Marija, Maculins, Timurs, De Piccoli, Giacomo, Labib, Karim
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300516/
https://ncbi.nlm.nih.gov/pubmed/25342810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1253596
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