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Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication
Chromosome replication is initiated by a universal mechanism in eukaryotic cells, involving the assembly and activation at replication origins of the CMG (Cdc45-MCM-GINS) DNA helicase, which is essential for the progression of replication forks. Disassembly of CMG is likely to be a key regulated ste...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4300516/ https://ncbi.nlm.nih.gov/pubmed/25342810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1253596 |
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