Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody

Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its indispensable role in infection. Here we show the c...

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Vydáno v:Nat Commun
Hlavní autoři: Chandramouli, Sumana, Ciferri, Claudio, Nikitin, Pavel A., Caló, Stefano, Gerrein, Rachel, Balabanis, Kara, Monroe, James, Hebner, Christy, Lilja, Anders E., Settembre, Ethan C., Carfi, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579600/
https://ncbi.nlm.nih.gov/pubmed/26365435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9176
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