Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies

Human Cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and in fetuses following congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are required for HCMV entry in fibroblasts and endothelial/epithelial cells, resp...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Ciferri, Claudio, Chandramouli, Sumana, Leitner, Alexander, Donnarumma, Danilo, Cianfrocco, Michael A., Gerrein, Rachel, Friedrich, Kristian, Aggarwal, Yukti, Palladino, Giuseppe, Aebersold, Ruedi, Norais, Nathalie, Settembre, Ethan C., Carfi, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617720/
https://ncbi.nlm.nih.gov/pubmed/26485028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005230
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