The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy

Guanine-rich oligonucleotides can fold into quadruple-stranded helical structures known as G-quadruplexes. Mounting experimental evidence has gathered suggesting that these non-canonical nucleic acid structures form in vivo and play essential biological roles. However, to date, there are no small-mo...

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Udgivet i:Nat Commun
Main Authors: Shivalingam, Arun, Izquierdo, M. Angeles, Marois, Alix Le, Vyšniauskas, Aurimas, Suhling, Klaus, Kuimova, Marina K., Vilar, Ramon
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579598/
https://ncbi.nlm.nih.gov/pubmed/26350962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9178
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