Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules

Cytoplasmic dynein is a dimeric AAA(+) motor protein that performs critical roles in eukaryotic cells by moving along microtubules using ATP. Here using cryo-electron microscopy we directly observe the structure of Dictyostelium discoideum dynein dimers on microtubules at near-physiological ATP conc...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Imai, Hiroshi, Shima, Tomohiro, Sutoh, Kazuo, Walker, Matthew L., Knight, Peter J., Kon, Takahide, Burgess, Stan A.
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579568/
https://ncbi.nlm.nih.gov/pubmed/26365535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9179
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