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Helix sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding

Coupling between ATPase and track-binding sites is essential for molecular motors to move along cytoskeletal tracks. In dynein, these sites are separated by a long coiled-coil stalk which must mediate communication between them, yet the underlying mechanism remains unclear. Here we show that changes...

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Detalhes bibliográficos
Main Authors: Kon, Takahide, Imamula, Kenji, Roberts, Anthony J., Ohkura, Reiko, Knight, Peter J., Gibbons, I. R., Burgess, Stan A., Sutoh, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757048/
https://ncbi.nlm.nih.gov/pubmed/19198589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1555
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