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Thiophene-expanded guanosine analogues of Gemcitabine

The chemotherapeutic drug Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine, has long been the standard of care for a number of cancers. Gemcitabine’s chemotherapeutic properties stem from its 2′,2′-difluoro-2′-deoxyribose sugar, which mimics the natural nucleoside, but also disrupts nucleic acid synthes...

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Foilsithe in:Bioorg Med Chem Lett
Main Authors: Chen, Zhe, Ku, Therese C., Seley-Radtke, Katherine L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579529/
https://ncbi.nlm.nih.gov/pubmed/26316465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.07.086
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