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Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2′-deoxy nucleoside analogues

Introducing structural diversity into the nucleoside scaffold for use as potential chemotherapeutics has long been considered an important approach to drug design. In that regard, we have designed and synthesized a number of innovative 2′-deoxy expanded nucleosides where a heteroaromatic thiophene s...

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Autors principals: Wauchope, Orrette R., Johnson, Cameron, Krishnamoorthy, Pasupathy, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Seley-Radtke, Katherine L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727052/
https://ncbi.nlm.nih.gov/pubmed/22464686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.03.004
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