Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation prot...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Ryu, Jae Kyu, Petersen, Mark A., Murray, Sara G., Baeten, Kim M., Meyer-Franke, Anke, Chan, Justin P., Vagena, Eirini, Bedard, Catherine, Machado, Michael R., Coronado, Pamela E. Rios, Prod'homme, Thomas, Charo, Israel F., Lassmann, Hans, Degen, Jay L., Zamvil, Scott S., Akassoglou, Katerina
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579523/
https://ncbi.nlm.nih.gov/pubmed/26353940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9164
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