Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage

Scar formation in the nervous system begins within hours after traumatic injury and is characterized primarily by reactive astrocytes depositing proteoglycans that inhibit regeneration. A fundamental question in CNS repair has been the identity of the initial molecular mediator that triggers glial s...

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Bibliographic Details
Main Authors: Schachtrup, Christian, Ryu, Jae K., Helmrick, Matthew J., Vagena, Eirini, Galanakis, Dennis K., Degen, Jay L., Margolis, Richard U., Akassoglou, Katerina
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871011/
https://ncbi.nlm.nih.gov/pubmed/20427645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0137-10.2010
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