Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation prot...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ryu, Jae Kyu, Petersen, Mark A., Murray, Sara G., Baeten, Kim M., Meyer-Franke, Anke, Chan, Justin P., Vagena, Eirini, Bedard, Catherine, Machado, Michael R., Coronado, Pamela E. Rios, Prod'homme, Thomas, Charo, Israel F., Lassmann, Hans, Degen, Jay L., Zamvil, Scott S., Akassoglou, Katerina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579523/
https://ncbi.nlm.nih.gov/pubmed/26353940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9164
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