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A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

We show that a common polymorphic variant in the ERCC5 5′ untranslated region (UTR) generates an upstream ORF (uORF) that affects both the background expression of this protein and its ability to be synthesized following exposure to agents that cause bulky adduct DNA damage. Individuals that harbor...

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מידע ביבליוגרפי
הוצא לאור ב:	Genes Dev
Main Authors:	Somers, Joanna, Wilson, Lindsay A., Kilday, John-Paul, Horvilleur, Emilie, Cannell, Ian G., Pöyry, Tuija A.A., Cobbold, Laura C., Kondrashov, Alexander, Knight, John R.P., Puget, Stéphanie, Grill, Jacques, Grundy, Richard G., Bushell, Martin, Willis, Anne E.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Cold Spring Harbor Laboratory Press 2015
נושאים:	Research Communication
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4579346/ https://ncbi.nlm.nih.gov/pubmed/26338418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.261867.115
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A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

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