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HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3

The accessory HIV protein Vpu inhibits a number of cellular pathways that trigger host innate restriction mechanisms. HIV Vpu-mediated degradation of tetherin allows efficient particle release and hampers the activation of the NF-κB pathway thereby limiting the expression of proinflammatory genes. I...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Manganaro, Lara, de Castro, Elisa, Maestre, Ana M., Olivieri, Kevin, García-Sastre, Adolfo, Fernandez-Sesma, Ana, Simon, Viviana
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577919/
https://ncbi.nlm.nih.gov/pubmed/26178989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01596-15
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