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HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3
The accessory HIV protein Vpu inhibits a number of cellular pathways that trigger host innate restriction mechanisms. HIV Vpu-mediated degradation of tetherin allows efficient particle release and hampers the activation of the NF-κB pathway thereby limiting the expression of proinflammatory genes. I...
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| Veröffentlicht in: | J Virol |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4577919/ https://ncbi.nlm.nih.gov/pubmed/26178989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01596-15 |
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