Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF-κB and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection

Hepatitis C virus (HCV) infection of hepatocytes leads to transcriptional induction of the chemokine CXCL10, which is considered an interferon (IFN)-stimulated gene. However, we have recently shown that IFNs are not required for CXCL10 induction in hepatocytes during acute HCV infection. Since the C...

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Hlavní autoři: Brownell, Jessica, Bruckner, Jacob, Wagoner, Jessica, Thomas, Emmanuel, Loo, Yueh-Ming, Gale, Michael, Liang, T. Jake, Polyak, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911583/
https://ncbi.nlm.nih.gov/pubmed/24257594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02007-13
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