Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

Loss of prolyl hydroxylase 2 (PHD2) activates the hypoxia-inducible factor-dependent hypoxic response, including anaerobic glycolysis, which causes large amounts of lactate to be released from cells into the circulation. We found that Phd2-null mouse embryonic fibroblasts (MEFs) produced more lactat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Suhara, Tomohiro, Hishiki, Takako, Kasahara, Masataka, Hayakawa, Noriyo, Oyaizu, Tomoko, Nakanishi, Tsuyoshi, Kubo, Akiko, Morisaki, Hiroshi, Kaelin, William G., Suematsu, Makoto, Minamishima, Yoji Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577207/
https://ncbi.nlm.nih.gov/pubmed/26324945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515872112
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge