Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

Loss of prolyl hydroxylase 2 (PHD2) activates the hypoxia-inducible factor-dependent hypoxic response, including anaerobic glycolysis, which causes large amounts of lactate to be released from cells into the circulation. We found that Phd2-null mouse embryonic fibroblasts (MEFs) produced more lactat...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Suhara, Tomohiro, Hishiki, Takako, Kasahara, Masataka, Hayakawa, Noriyo, Oyaizu, Tomoko, Nakanishi, Tsuyoshi, Kubo, Akiko, Morisaki, Hiroshi, Kaelin, William G., Suematsu, Makoto, Minamishima, Yoji Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577207/
https://ncbi.nlm.nih.gov/pubmed/26324945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515872112
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