Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression

MAPKs are activated in response to G protein-coupled receptor (GPCR) stimulation and play essential roles in regulating cellular processes downstream of these receptors. However, very little is known about the reciprocal effect of MAPK activation on GPCRs. To investigate possible crosstalk between t...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Paradis, Justine S., Ly, Stevenson, Blondel-Tepaz, Élodie, Galan, Jacob A., Beautrait, Alexandre, Scott, Mark G. H., Enslen, Hervé, Marullo, Stefano, Roux, Philippe P., Bouvier, Michel
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577186/
https://ncbi.nlm.nih.gov/pubmed/26324936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508836112
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