Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering

Enzyme I (EI) is the first component in the bacterial phosphotransferase system, a signal transduction pathway in which phosphoryl transfer through a series of bimolecular protein–protein interactions is coupled to sugar transport across the membrane. EI is a multidomain, 128-kDa homodimer that has...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Venditti, Vincenzo, Schwieters, Charles D., Grishaev, Alexander, Clore, G. Marius
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577164/
https://ncbi.nlm.nih.gov/pubmed/26305976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515366112
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