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DGCR8 is essential for tumor progression following PTEN loss in the prostate
In human prostate cancer, the microRNA biogenesis machinery increases with prostate cancer progression. Here, we show that deletion of the Dgcr8 gene, a critical component of this complex, inhibits tumor progression in a Pten-knockout mouse model of prostate cancer. Early stages of tumor development...
Guardat en:
| Publicat a: | EMBO Rep |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley & Sons, Ltd
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4576988/ https://ncbi.nlm.nih.gov/pubmed/26206718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439925 |
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