DGCR8 is essential for tumor progression following PTEN loss in the prostate

In human prostate cancer, the microRNA biogenesis machinery increases with prostate cancer progression. Here, we show that deletion of the Dgcr8 gene, a critical component of this complex, inhibits tumor progression in a Pten-knockout mouse model of prostate cancer. Early stages of tumor development...

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Bibliografische gegevens
Gepubliceerd in:EMBO Rep
Hoofdauteurs: Belair, Cassandra D, Paikari, Alireza, Moltzahn, Felix, Shenoy, Archana, Yau, Christina, Dall’Era, Marc, Simko, Jeff, Benz, Christopher, Blelloch, Robert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Ltd 2015
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576988/
https://ncbi.nlm.nih.gov/pubmed/26206718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439925
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