DGCR8 is essential for tumor progression following PTEN loss in the prostate

In human prostate cancer, the microRNA biogenesis machinery increases with prostate cancer progression. Here, we show that deletion of the Dgcr8 gene, a critical component of this complex, inhibits tumor progression in a Pten-knockout mouse model of prostate cancer. Early stages of tumor development...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO Rep
Egile Nagusiak: Belair, Cassandra D, Paikari, Alireza, Moltzahn, Felix, Shenoy, Archana, Yau, Christina, Dall’Era, Marc, Simko, Jeff, Benz, Christopher, Blelloch, Robert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley & Sons, Ltd 2015
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576988/
https://ncbi.nlm.nih.gov/pubmed/26206718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439925
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