Biodistribution and Efficacy of Targeted Pulmonary Delivery of a Protein Kinase C-δ Inhibitory Peptide: Impact on Indirect Lung Injury

Sepsis and sepsis-induced lung injury remain a leading cause of death in intensive care units. We identified protein kinase C-δ (PKCδ) as a critical regulator of the acute inflammatory response and demonstrated that PKCδ inhibition was lung-protective in a rodent sepsis model, suggesting that target...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Pharmacol Exp Ther
Egile Nagusiak: Mondrinos, Mark J., Knight, Linda C., Kennedy, Paul A., Wu, Jichuan, Kauffman, Matthew, Baker, Sandy T., Wolfson, Marla R., Kilpatrick, Laurie E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2015
Gaiak:
Inflammation, Immunopharmacology, and Asthma
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576664/
https://ncbi.nlm.nih.gov/pubmed/26243739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.224832
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