Biodistribution and Efficacy of Targeted Pulmonary Delivery of a Protein Kinase C-δ Inhibitory Peptide: Impact on Indirect Lung Injury

Sepsis and sepsis-induced lung injury remain a leading cause of death in intensive care units. We identified protein kinase C-δ (PKCδ) as a critical regulator of the acute inflammatory response and demonstrated that PKCδ inhibition was lung-protective in a rodent sepsis model, suggesting that target...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Mondrinos, Mark J., Knight, Linda C., Kennedy, Paul A., Wu, Jichuan, Kauffman, Matthew, Baker, Sandy T., Wolfson, Marla R., Kilpatrick, Laurie E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Inflammation, Immunopharmacology, and Asthma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576664/
https://ncbi.nlm.nih.gov/pubmed/26243739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.224832
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