How an Inhibitor Bound to Subunit Interface Alters Triosephosphate Isomerase Dynamics

The tunnel region at triosephosphate isomerase (TIM)’s dimer interface, distant from its catalytic site, is a target site for certain benzothiazole derivatives that inhibit TIM’s catalytic activity in Trypanosoma cruzi, the parasite that causes Chagas disease. We performed multiple 100-ns molecular-...

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Dades bibliogràfiques
Publicat a:Biophys J
Autors principals: Kurkcuoglu, Zeynep, Findik, Doga, Akten, Ebru Demet, Doruker, Pemra
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2015
Matèries:
Proteins and Nucleic Acids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576151/
https://ncbi.nlm.nih.gov/pubmed/26190635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.031
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