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How an Inhibitor Bound to Subunit Interface Alters Triosephosphate Isomerase Dynamics
The tunnel region at triosephosphate isomerase (TIM)’s dimer interface, distant from its catalytic site, is a target site for certain benzothiazole derivatives that inhibit TIM’s catalytic activity in Trypanosoma cruzi, the parasite that causes Chagas disease. We performed multiple 100-ns molecular-...
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| Publicado no: | Biophys J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4576151/ https://ncbi.nlm.nih.gov/pubmed/26190635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.031 |
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