A Molecular Dynamics Study of Allosteric Transitions in Leishmania mexicana Pyruvate Kinase

A comparative molecular dynamics analysis of the pyruvate kinase from Leishmania mexicana is presented in the absence and presence of the allosteric effector fructose 2,6-bisphosphate. Comparisons of the simulations of the large 240 kDa apo and holo tetramers show that binding of fructose 2,6-bispho...

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Bibliographic Details
Published in:Biophys J
Main Authors: Naithani, Ankita, Taylor, Paul, Erman, Burak, Walkinshaw, Malcolm D.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576150/
https://ncbi.nlm.nih.gov/pubmed/26210208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.05.040
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