An Antifungal Benzimidazole Derivative Inhibits Ergosterol Biosynthesis and Reveals Novel Sterols

Fungal infections are a leading cause of morbidity and death for hospitalized patients, mainly because they remain difficult to diagnose and to treat. Diseases range from widespread superficial infections such as vulvovaginal infections to life-threatening systemic candidiasis. For systemic mycoses,...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Keller, Petra, Müller, Christoph, Engelhardt, Isabel, Hiller, Ekkehard, Lemuth, Karin, Eickhoff, Holger, Wiesmüller, Karl-Heinz, Burger-Kentischer, Anke, Bracher, Franz, Rupp, Steffen
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2015
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Mechanisms of Action: Physiological Effects
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576113/
https://ncbi.nlm.nih.gov/pubmed/26248360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00640-15
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