An Antifungal Benzimidazole Derivative Inhibits Ergosterol Biosynthesis and Reveals Novel Sterols

Fungal infections are a leading cause of morbidity and death for hospitalized patients, mainly because they remain difficult to diagnose and to treat. Diseases range from widespread superficial infections such as vulvovaginal infections to life-threatening systemic candidiasis. For systemic mycoses,...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Keller, Petra, Müller, Christoph, Engelhardt, Isabel, Hiller, Ekkehard, Lemuth, Karin, Eickhoff, Holger, Wiesmüller, Karl-Heinz, Burger-Kentischer, Anke, Bracher, Franz, Rupp, Steffen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576113/
https://ncbi.nlm.nih.gov/pubmed/26248360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00640-15
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